The high end modelers (Fractal, Line 6 Helix, Quad Cortex, etc) are all used a lot with touring bands. The low end is the Boss Katana and also the Line 6 Catalyst, which has some of the Helix models and FX and sounds great. I have also seen a move toward the lower end Tone X and HEADRUSH run through powered speakers as a lot of companies are buileding powered cabs. For a while, the Fender Tonemaster Twin, Deluxe and Super were getting popular and I have to admit they were great. Their drawback was that they used all of their DSP recreating the Fender tone which was great if all you wanted to do is have Fender tones.. I still use tube amps for my more serious stuff but have lately been using the Quad Cortex along with the Line 6 powercab for smaller gigs. Nobody has complained at all about my tone in using it. The models sound great but I still can feel something lacking in their response to my fingers.
I would have no trouble using the Katana or the Catalyst soundwise. Using a Fender Tonemaster is simple in that it is built exactly like a Fender, so plug in and play. The Tone X, Katana and Catalyst require a few minutes of figuing out how to set them up in order to get the most out of them